The cannabis sector is lighting up in 2025 with fresh energy as Trump floats reclassifying marijuana, opening new doors for industry growth and investor optimism. Curaleaf’s (CURLF), stock has climbed more than 83% year-to-date (YTD), while Trulieve Cannabis (TCNNF), also rose by 52.66% YTD.
This surge in momentum is echoed on a global scale, with the medical cannabis market projected to grow at a compound annual rate of 22.5% from 2025 to 2035 as legalization broadens and demand for alternative therapies rises.
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Riding this momentum, the AdvisorShares Pure US Cannabis ETF (MSOS) stands out as the best-performing cannabis ETF of 2025. It has posted a gain of over 30% so far this year and offered investors a powerful entry to America’s most dynamic cannabis companies.
Will MSOS keep its lead as the sector’s breakout success, or is more volatility on the horizon? Let’s dive into MSOS and see what it has to offer.
The AdvisorShares Pure US Cannabis ETF distinguishes itself with a single-minded, actively managed strategy concentrating exclusively on U.S. cannabis companies, with particular emphasis on multi-state operators. The selective approach is all about targeting American firms participating directly in cultivation, retail, technology, and ancillary services related to cannabis.
This keeps the portfolio focused and sidesteps the confusion of less accessible OTC-listed or foreign cannabis stocks. The result is simplified access paired with greater transparency and liquidity for its shares.
Originating from the AdvisorShares fund family, MSOS officially launched with an inception date of Sept. 1, 2020, and began trading just two days later. Since then, the fund has grown to manage $712.7 million in assets, reflecting both market interest and the expansive reach of its approach.
The ETF maintains a relatively concentrated portfolio with 26 total stocks, but what stands out is that the top 10 holdings collectively account for 142.08% of assets, reflecting both conviction and the use of swaps for regulatory-compliant exposure. The top positions include Curaleaf (22.63%), Green Thumb Industries (GTBIF) (21.61%), Trulieve Cannabis (20.95%), Verano Holdings (VRNOF) (7.72%), TerrAscend (TSNDF) (6.11%), Cresco Labs (CRLBF) (6.10%), Glass House Brands (GLASF) (5.61%), Jushi Holdings (JUSHF) (2.24%), Cannabist Company (CBSTF) (0.77%), and Village Farms International (VFF) (0.71%).